Dydrogesterone: What It Is, How It Works, and What Alternatives Exist

When your body doesn’t make enough dydrogesterone, a synthetic form of the hormone progesterone used to regulate the menstrual cycle and support early pregnancy. Also known as Duphaston, it’s not just another hormone pill—it’s a targeted tool for women dealing with irregular periods, recurrent miscarriages, or infertility linked to low progesterone. Unlike natural progesterone, dydrogesterone is designed to be taken orally without breaking down too fast in the liver, which means it works longer and more reliably. It doesn’t turn into other hormones like some others do, so side effects tend to be milder. That’s why doctors often pick it over older options when they need something precise.

It’s closely related to progesterone therapy, the broader category of treatments that replace or supplement the body’s natural progesterone to fix hormonal imbalances. But dydrogesterone isn’t the only player. Other options include micronized progesterone, medroxyprogesterone, and even natural supplements like chasteberry—each with different strengths, side effects, and uses. For example, if you’re trying to get pregnant, dydrogesterone is often preferred because studies show it supports the uterine lining better than some alternatives. If you’re treating endometriosis or PMS, your doctor might switch you to something else based on how your body reacts.

People use dydrogesterone for more than just fertility. It’s also prescribed for menstrual disorders, conditions like amenorrhea, heavy bleeding, or luteal phase defect that disrupt the normal cycle. It’s not a cure-all, but for many, it brings back regular periods without the mood swings or bloating you get with other hormones. And unlike some progesterone shots or creams, it’s easy to take—just one pill a day. You don’t need a clinic visit or special storage. That’s part of why it’s become a go-to in clinics across Europe and beyond.

Still, it’s not for everyone. If you have liver disease, certain types of cancer, or a history of blood clots, your doctor will skip dydrogesterone. And while it’s generally well-tolerated, some people report headaches, breast tenderness, or light spotting. That’s why matching the right hormone to your body matters. The posts below dive into exactly that: how dydrogesterone stacks up against other treatments, what real patients report, and how to know if it’s the right fit for your situation. You’ll find clear comparisons, real-world experiences, and practical advice on when to choose it—and when to look elsewhere.